Sökning: "pKa"

Visar resultat 1 - 5 av 162 avhandlingar innehållade ordet pKa.

  1. 1. Calibration of Ionization Chambers for Measuring Air Kerma Integrated over Beam Area in Diagnostic Radiology

    Författare :Peter Larsson; Gudrun Alm Carlsson; Jan Persliden; Bertil Axelsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KAP-meter; DAP-meter; PKA; kerma area product; energy dependence; calibration; Radiological physics; Radiofysik;

    Sammanfattning : The air kerma area product PKA is an important quantity used by hospital physicists in quality assurance and optimization processes in diagnostic radiology and is recommended by national authorities for setting of diagnostic reference levels. PKA can be measured using a transmission ionization chamber (kerma area product (KAP) meter) mounted on the collimator housing. LÄS MER

  3. 2. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

    Författare :Peter Wiklund; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER

  4. 3. Physicochemical and Structural Aspects of Nucleic Acids

    Författare :Subhrangsu Chatterjee; Adolf Gogoll; Helena Grennberg; Göran Widmalm; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; pKa; Hydrogen bonding; Stacking; NMR; MD; DNA; RNA; Pyrimidine; Organisk kemi;

    Sammanfattning : This thesis consists of seven research publications concerning (i) pKa studies of nucleobases in model nucleotides to understand why RNA duplexes are more stable than DNA duplexes (Paper I), (ii) the role of Me(T)-π interactions in the relative stability of DNA-RNA heteroduplexes (Paper II), (iii) pKa measurements in nucleotides with different 2′-substituents (paper III), (iv) a conformation study of constrained sugars and a pKa study of 1-thyminyl to reveal effect of sugar constraints on the pKa of the nucleobase (paper IV), (v) NMR and MD studies of 1′, 2′-oxetane constrained thymidine incorporated Dickerson Drew dodecamer (paper V), (vi) the sequence dependent pKa perturbation of 9-guaninyl moeity in single stranded (ss) DNA and RNA (paper VI), (vii) the non identical chemical nature of internucleotidic phosphates in (ss) RNA using 31P NMR (paper VI), and an alkaline hydrolysis study of phosphodiesters in ssRNAs (paper VII). The architecture of DNA and RNA molecules is determined by (a) hydrogen bonding (b) base stacking (c) a variety of additional non-covalent interactions. LÄS MER

  5. 4. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing

    Författare :Heidi Törmänen Persson; Göran Akusjärvi; Stefan Schwartz; Marie Öhman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-33K; adenovirus; splicing; phosphorylation; localization; replication centers; L4-22K; MLTU; DNA-PK; DNA-dependent protein kinase; PKA; cAMP-dependent protein kinase; transcription sites; SR protein; Medical Virology; Medicinsk virologi;

    Sammanfattning : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. LÄS MER

  7. 5. Green Colloid Chemistry: Characterization of Environmentally Friendly Nonionic Surfactant Systems

    Författare :Christy Whiddon; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nucleophilic substitution; alkylglucosides; bicontinious micelles; self-diffusion NMR; nonionic surfactants; micellar catalysis; Physical chemistry; pKa; Fysikalisk kemi;

    Sammanfattning : Phase diagrams of mixed alkylglucoside surfactants, n-nonyl-b-D-glucopyranoside and n-decyl-b-D-glucopyranoside (C9G1 and C10G1) have been examined for the purpose of determining the microstructure surrounding a closed-loop miscibiliyt gap. There are large deuterium isotope effects on the phase diagram. LÄS MER