Sökning: "drug regulation"

Visar resultat 6 - 10 av 370 avhandlingar innehållade orden drug regulation.

  1. 6. On the Optimisation and Regulation of Clinical Trials

    Författare :Sebastian Jobjörnsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; decision theory; Bayesian statistics; optimal stopping.; clinical trials; subgroup analysis; drug regulation;

    Sammanfattning : The basic premise of this thesis is that Bayesian Decision Theory (BDT) can and should be used to solve clinical trial design problems. While the flexibility of the framework allows for accommodating a great variety of situations, it also requires an explicit consideration of the gains and costs associated with the trial. LÄS MER

  3. 7. Structural studies of drug targets and a drug metabolizing enzyme

    Författare :Daniela Cederfelt; U. Helena Danielson; Doreen Dobritzsch; Inari Kursula; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biophysics; Protein structure; X-ray crystallography; Cryogenic electron microscopy; Enzymology; Drug discovery; Pyrimidine degradation; Biokemi; Biochemistry;

    Sammanfattning : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. LÄS MER

  4. 8. Protease Activity, Inhibition and Ligand Interaction Analysis : Developments and Applications for Drug Discovery

    Författare :Thomas Gossas; Helena Danielson; Mikael Widersten; Alexander Wlodawer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; proteases; kinetics; biosensors; inhibition; calcium; drug discovery; Biokemi;

    Sammanfattning : The present study has focused on characterising protease-ligand interactions in the context of drug discovery. The proteases that have been studied are human matrix metallopeptidase 12 (MMP-12), HIV-protease and Hepatitis C virus (HCV) NS3/NS4A protease. LÄS MER

  5. 9. On Nogo signaling regulation

    Författare :Alexandra Trifunovski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nogo; Nogo receptor; regulation; neurotrophin; Lingo-1; p75NTR; Troy; synaptic plasticity;

    Sammanfattning : As neuronal development enters its final stages, axon growth becomes restricted. This lack of regenerative capacity is partly due to the non-permissive environment of growth inhibitory proteins. Three such proteins, Nogo, OMgp and MAG bind to the same receptor, the Nogo receptor (NgR) and induce growth cone collapse and axon growth inhibition. LÄS MER

  7. 10. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Författare :Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Sammanfattning : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. LÄS MER