Sökning: "bacterial fitness"

Visar resultat 1 - 5 av 55 avhandlingar innehållade orden bacterial fitness.

  1. 1. Bacterial Resistance to Antimicrobial Peptides : Rates, Mechanisms and Fitness Effects

    Författare :Maria Pränting; Dan Andersson; Ian Chopra; Uppsala universitet; []
    Nyckelord :antimicrobial peptides; antibiotic resistance; fitness cost; bacterial evolution; small colony variants; cyclotides; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Mikrobiologi; Microbiology;

    Sammanfattning : The rapid emergence of bacterial resistance to antibiotics has necessitated the development of alternative treatment strategies. Antimicrobial peptides (AMPs) are important immune system components that kill microbes rapidly and have broad activity-spectra, making them promising leads for new pharmaceuticals. LÄS MER

  3. 2. Removal and Replacement of Ribosomal Proteins : Effects on Bacterial Fitness and Ribosome Function

    Författare :Christina Tobin; Dan I. Andersson; Richard Buckingham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ribosome; protein synthesis; ribosomal proteins; translation initiation; ribosome biogenesis; fitness costs; compensatory evolution; horizontal gene transfer; Microbiology; Mikrobiologi; Biochemistry; Biokemi; Mikrobiologi; Microbiology;

    Sammanfattning : Protein synthesis is a complex process performed by sophisticated cellular particles known as ribosomes. Although RNA constitutes the major structural and functional component, ribosomes from all kingdoms contain an extensive array of proteins with largely undefined functional roles. LÄS MER

  4. 3. Experimental Evolution : and Fitness Effects of Mutations

    Författare :Anna Knöppel; Dan I Andersson; Stanley Maloy; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Fitness effects; mutations; S20; fis; ribosome; horizontal gene transfer; adaptation; synonymous mutations; Mikrobiologi; Microbiology;

    Sammanfattning : Bacteria have small, streamlined genomes and evolve rapidly. Their large population sizes allow selection to be the main driver of evolution. With advances in sequencing technologies and precise methods for genetic engineering, many bacteria are excellent models for studying elementary questions in evolutionary biology. LÄS MER

  5. 4. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

    Författare :Marius Linkevičius; Dan I. Andersson; Linus Sandegren; Patrice Courvalin; Uppsala universitet; []
    Nyckelord :Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

    Sammanfattning : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. LÄS MER

  7. 5. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

    Författare :Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER