Sökning: "common factor models"

Visar resultat 36 - 40 av 238 avhandlingar innehållade orden common factor models.

1. 36. Mixed Effects Modelling and Optimal Design of TNFα Response in LPS Challenge Studies - Methods and Applications in Drug Discovery

   Författare :Julia Larsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacodynamics; pharmacokinetics; non-linear mixed effects modelling; lipopolysaccharides; tumour necrosis factor alpha; optimal design;

   Sammanfattning : ''Endotoxin and mycoplasma are Nature’s darkest secrets. If they are ever solved, Hell itself will open.'' - Lewis Thomas* Endotoxin, or lipopolysaccharides (LPS), are heterogeneous components from the cell wall of Gram-Negative bacteria and a common challenger in the field of drug discovery. LÄS MER

3. 37. Continuity of care after hospitalization due to cardiac conditions : Patients' perceptions, validity and reliability of a measure, and associations with outcomes

   Författare :Emma Säfström; Anna Strömberg; Tiny Jaarsma; Maria Liljeroos; Lena Nordgren; Anna Forsberg; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac disease; Conceptual models of nursing; Continuity of care; Discharge planning; Perceived control; Psychometrics; Quality of care; Quality of life; Self-care; Validation studies;

   Sammanfattning : Background: Cardiac conditions are a common cause of hospitalization worldwide. The need for healthcare continues after hospital discharge and most commonly includes follow-up within primary healthcare centers or specialized outpatient cardiology clinics. LÄS MER

4. 38. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses

   Författare :Milagrosa López Riego; Andrzej Wojcik; Lovisa Lundholm; Alexandros G. Georgakilas; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionising radiation; low dose; low dose rate; linear energy transfer LET ; mixed beams; dose and dose rate effectiveness factor DDREF ; cancer; DNA damage response; biomarkers; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. LÄS MER

5. 39. Drug and alcohol induced hepatotoxicity

   Författare :Angelica Butura; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatotoxicity; in vitro models; alcoholic liver disease; CYP2E1;

   Sammanfattning : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. LÄS MER

7. 40. Transcriptome based analysis of Hodgkin lymphoma : insights into the microenvironment

   Författare :Anna Birgersdotter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hodgkin lymphoma; Epstein-Barr virus; gene expression; tissue culture; cell-line models;

   Sammanfattning : This thesis is focused on the analysis of Hodgkin lymphoma (HL), in particular the complex interaction between the malignant cells and the abnormally behaving bystander cells, and this complexity of the inflammatory infiltrate in HL constantly challenge scientists. The common thread in this thesis is the usage of gene expression profiling of whole tumour tissues, laser-captured Hodgkin Reed Sternberg (H-RS) cells and of cell-lines. LÄS MER