Sökning: "CYP2E1"
Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet CYP2E1.
1. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa
Sammanfattning : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). LÄS MER
2. Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects
Sammanfattning : Cytochrome P450s constitute a superfamily of heme-binding monooxygenases that play important roles in the metabolism of endogenous substrates and a wide variety of exogenous substances, such as toxins and drugs, and participate as well in the biosynthesis of steroids, fatty acids, vitamins and bile acids. The P450s genes are subjects for large inter-individual variability in expression, which subsequently cause inter-individual differences in drug metabolism. LÄS MER
3. Drug and alcohol induced hepatotoxicity
Sammanfattning : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. LÄS MER
4. Variation and comparison of cytochromes P450 in human liver and blood : with special emphasis on gene expression
Sammanfattning : The liver is the major drug and xenobiotic metabolising organ, and is the target of many adverse reactions. The main hepatic metabolic enzymes belong to the mono oxygenase enzyme family of cytochromes P450 (CYP). Direct studies of these enzymes in small liver biopsy samples require ultrasensitive methodology. LÄS MER
5. Regulation of cytochrome P450 2E1 by hyperoxia and inflammatory factors, with special reference to the central nervous system
Sammanfattning : Cytochrome P450 2E1 (CYP2E1) is a mammalian member of the large P450 gene superfamily. CYP2E1 is active in the metabolism of many small hydrophobic substrates, including general anesthetics, muscle relaxants, precarcinogens, and organic solvents. LÄS MER