Sökning: "common factor models"
Visar resultat 21 - 25 av 238 avhandlingar innehållade orden common factor models.
21. Pharmacometric models in the development of biological medicinal products
Sammanfattning : Biological medicinal products (BMPs) are a successful class of drugs that are indicated in numerous diseases. Common among them is that complexities associated with their manufacture and analysis lead to a high cost compared to small-molecular weight drugs. LÄS MER
22. Beta Cell Function: from Human Genetics to Animal Models
Sammanfattning : Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. LÄS MER
23. Galanin receptor subtypes in rodent models of mood disorders
Sammanfattning : Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life events seems to be a common, contributing cause of morbidity. LÄS MER
24. Obesity in diabetes. Cardiovascular outcomes and risk factor trajectories
Sammanfattning : Introduction: The association between body mass index (BMI) and mortality in diabetes is complex and sparsely investigated for cardiovascular (CVD) outcomes. We aimed to investigate these relationships among patients with type 1 and type 2 diabetes using data from the Swedish national diabetes registry (NDR), with focus on potential reverse causality. LÄS MER
25. Protective Mechanical Ventilation in Inflammatory and Ventilator-Associated Pneumonia Models
Sammanfattning : Severe infections, trauma or major surgery can each cause a state of systemic inflammation. These causes for systemic inflammation often coexist and complicate each other. Mechanical ventilation is commonly used during major surgical procedures and when respiratory functions are failing in the intensive care setting. LÄS MER