Sökning: "class II MHC"

Visar resultat 36 - 40 av 180 avhandlingar innehållade orden class II MHC.

1. 36. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

   Författare :Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

   Sammanfattning : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. LÄS MER

3. 37. Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts

   Författare :Manal Mustafa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Triclosan; gingival fibroblasts; IL-beta; IFN-gamma; MHC class II; PGE2; mPGES-1;

   Sammanfattning : Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is a lipid soluble anti-bacterial agent widely used in dentifrices, mouthrinses, soap and cosmetics. Although reports on the efficacy of triclosan on periodontal diseases are conflicting, it is documented in clinical studies that dentifrices containing triclosan reduce plaque accumulation and improve gingival health. LÄS MER

4. 38. Genetics and inflammation in nerve injury-induced neurodegeneration

   Författare :Olle Lidman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Axotomy; Motoneuron; Neurodegeneration; Immunity; Microglia; MHC; QTL Mapping.;

   Sammanfattning : Neurodegeneration and inflammation are characteristic of many diseases of the central nervous system (CNS) and understanding the molecular networks that regulate these processes is of central importance for the development of effective therapies. Although the CNS has traditionally been regarded as an immuno privileged organ, immune reactions, including components of both local innate and systemic immunity, do occur in this tissue. LÄS MER

5. 39. Human leukocyte antigens with special reference to association and linkage in multiple sclerosis

   Författare :Anna Fogdell-Hahn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HLA; MHC; multiple sclerosis; narcolepsy; lod score; linkage.;

   Sammanfattning : The polymorphism of HLA (human leukocyte antigen) is extensive. Allelic variation has previously been detected by cellular and serological methods. Today a variety of genomic typing techniques have been developed, which give higher resolution and a possibility to detect single nucleotide variations. LÄS MER

7. 40. Functional studies of T-cells in rheumatoid arthritis

   Författare :Louise Berg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T-cells; Rheumatoid arthritis; inflammation; cytokines; collagen type II; immunomodulation;

   Sammanfattning : Rheumatoid arthritis (RA) is a systemic inflammatory disease with autoimmune features primarily affecting the joints. The etiology of RA is largely unknown but involvement of the immune system in the disease process is evident from the infiltration of leukocytes into the joint, and by the production of proinflammatory cytokines, chemokines and proteases, mainly by macrophages. LÄS MER