Sökning: "class II MHC"

Visar resultat 21 - 25 av 180 avhandlingar innehållade orden class II MHC.

1. 21. Genetic Factors and Nasal Tolerance in Rat Models for Rheumatoid Arthritis

   Författare :Shemin Lu; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal tolerance; linkage analysis; MHC; genetics; pristane induced arthritis; rheumatoid arthritis; collagen induced arthritis; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : We used three animal models of rats for rheumatoid arthritis (RA) in this study. Firstly, We found that CXI induced arthritis (CXIIA) is associated with the RT1 f haplotype and follows a chronic disease course affecting peripheral joints with both progression and relapses. LÄS MER

3. 22. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions

   Författare :David Andersson; Anna Linusson Jonsson; Gabriele Cruciani; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; Pharmaceutical chemistry; Läkemedelskemi; datorlingvistik; computational linguistics;

   Sammanfattning : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. LÄS MER

4. 23. The MHC genes: variation and impact on life-history traits in house sparrwos

   Författare :Maria Karlsson; MEMEG; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC-I; house sparrow; 454-amplicon sequencing; cDNA; functional clustering; trans-species evolution; nestling survival; mate-choice;

   Sammanfattning : In birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. LÄS MER

5. 24. Binding and immunogenicity of MHC class-I specific peptides and glycopeptides

   Författare :Ussama M Abdel-Motal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Short synthetic MHC class I (MHC-I) Db and Kb binding peptides were found to be strongly immunogenic and capable of inducing virus-specific cytotoxic T lymphocyte (CTL) responses. Restimulation of primed splenocytes with a low peptide concentration generated optimal CTL responses. LÄS MER

7. 25. European Black Grouse : MHC Genetic Diversity and Population Structure

   Författare :Tanja Strand; Jacob Höglund; Helena Westerdahl; David S. Richardson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Major Histocompatibility Complex; BLB; balancing selection; concerted evolution; bottleneck; fragmentation; 3 UTR; Biologi med inriktning mot populationsbiologi; Biology with specialization in Population Biology;

   Sammanfattning : Black grouse Tetrao tetrix is a bird species composed of large, continuous as well as severely reduced and fragmented populations, making it an optimal species to investigate how genetic diversity is affected by habitat fragmentation. I have focused on genetic diversity in the Major Histocompatibility Complex (MHC) to measure the ability of the black grouse to respond to environmental changes. LÄS MER