Sökning: "class II MHC"

Visar resultat 31 - 35 av 180 avhandlingar innehållade orden class II MHC.

  1. 31. MHC class I restricted and antigen-specific TCRs against viral and tumor-associated antigens (TAAs) for future biological therapy

    Författare :Zhenjiang Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adoptive cellular immunotherapy (ACT) refers to the process of transferring immune cells (autologous or allogeneic) directly to the host as a treatment for cancer or infectious diseases. The effector cells could be antigen-specific, like T cells, or non-specific, such as NK cells or lymphokine-activated killer (LAK) cells. LÄS MER

  3. 32. HLA class I maturation - in the presence and absence of tapasin

    Författare :Linda Geironson Ulfsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Human leukocyte antigen class I (HLA-I) molecules are present on all nucleated cells and present the cell content to cytotoxic T lymphocytes in the form of peptides. Maturation of HLA-I occurs in the endoplasmic reticulum and results in stable peptide-HLA-I complexes, in the presence of proper quality control. LÄS MER

  4. 33. Structural and Functional Studies on Posttranslational Modifications of Collagen type II in Rheumatoid Arthritis

    Författare :Hüseyin Uysal; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The molecular mechanisms behind the development and progression of rheumatoid arthritis are not known in fine details. Both humoral and cellular responses against collagen type II in joint cartilage seems to be important for the disease development. LÄS MER

  5. 34. The MHC and the recognition of self and altered self in experimental and rheumatoid arthritis

    Författare :Sabrina Haag; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Major histocompatibility complex (MHC) is a highly polymorphic and gene-dense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity. LÄS MER

  7. 35. MHC polymorphism and host-pathogen interactions: The case of Borrelia in its reservoir host, the bank vole Myodes glareolus

    Författare :Kristin Scherman; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Host-pathogen interaction; Negative frequency dependent selection; Myodes glareolus; Borrelia;

    Sammanfattning : The major histocompatibility complex (MHC) class IIB genes exhibit extensive allelic polymorphism, most likely maintained by pathogen-mediated balancing selection (PMBS). PMBS may operate in the form of heterozygote advantage (HA), and/or through the interaction of pathogens and specific MHC alleles via fluctuating selection (FS) or negative frequency-dependent selection (NFDS). LÄS MER