Sökning: "QTL Mapping."

Visar resultat 1 - 5 av 56 avhandlingar innehållade orden QTL Mapping..

1. 1. Chicken Genomics - Linkage and QTL mapping

   Författare :Per Wahlberg; Leif Andersson; Ruedi Fries; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chicken; quantitative genetics; linkage map; QTL mapping; recombination; long-term selection; Z chromosome; selective sweep; SNP; Genetics; Genetik;

   Sammanfattning : This thesis presents results from genetic studies conducted in the chicken (Gallus gallus). The domestication of chicken is believed to have been initiated approximately 7,000 – 9,000 years ago in Southeast Asia. LÄS MER

3. 2. Genetic Studies of Rheumatoid Arthritis using Animal Models

   Författare :Niklas Nordquist; William Dietrich; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. LÄS MER

4. 3. Numerical methods for mapping of multiple QTL

   Författare :Kajsa Ljungberg; Sverker Holmgren; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Beräkningsvetenskap; Scientific Computing;

   Sammanfattning : This thesis concerns numerical methods for mapping of multiple quantitative trait loci, QTL. Interactions between multiple genetic loci influencing important traits, such as growth rate in farm animals and predisposition to cancer in humans, make it necessary to search for several QTL simultaneously. LÄS MER

5. 4. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

   Författare :Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
   Nyckelord :Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

   Sammanfattning : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. LÄS MER

7. 5. Domestication Effects on the Stress Response in Chickens : Genetics, Physiology, and Behaviour

   Författare :Amir Fallahshahroudi; Per Jensen; Frank Albert; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Animal domestication; stress response; gene expression; QTL; eQTL;

   Sammanfattning : Animal domestication, the process where animals become adapted to living in proximity to humans, is associated with the alteration of multiple traits, including decreased fearfulness and stress response. With an estimated population of 50 billion, the domesticated chicken is the most populous avian species in the world. LÄS MER