Sökning: "class II MHC"

Visar resultat 26 - 30 av 180 avhandlingar innehållade orden class II MHC.

  1. 26. Studies of cytotoxic T lymphocytes and natural killer cells in relation to MHC class I presented peptides

    Författare :Lars Franksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T-cell; NK cell; MHC class I; peptide;

    Sammanfattning : In the defense against disease it is essential for the immune system to be able to discriminate self/normal from non-self/abnormal. This key feature of the immune system relies on the presentation of antigens by MHC class I and class II molecules. LÄS MER

  3. 27. Immunoecology of the Great Snipe (Gallinago media) : Mate Choice, MHC Variation, and Humoral Immunocompetence in a Lekking Bird

    Författare :Robert Ekblom; Jacob Höglund; Mats Grahn; Scott V. Edwards; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Behaviour; Major histocompatibility complex class II B; Sexual selection; Evolution; Leks; Biologi; Biology; Biologi;

    Sammanfattning : At the centre of the vertebrate immune system is a group of proteins called MHC (major histocompatibility complex) molecules. These function in self – non self recognition and activation of the immune defence against intruding parasites and pathogens. LÄS MER

  4. 28. Mapping of the specificity in MHC class I recognition by natural killer cells

    Författare :Margareta Waldenström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells represent the third major lymphocyte subpopulation. They are distinguishable from B and T lymphocytes by their surface phenotype, cytokine profile and the ability to mediate spontaneous cytotoxicity, without prior sensitization, against certain tumor cells and virally infected cells. LÄS MER

  5. 29. Processing of live and heat inactivated Sendai virus for presentation on MHC class I molecules

    Författare :Tianmin Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antigen presentation; antigen processing; APC; CTL; MHC class1; peptides; Sendai virus; TAP;

    Sammanfattning : The present thesis deals with processing of antigens from live and heat inactivated Sendai virus and their loading on MHC class I molecules for presentation to CTL. In paper I it was observed surprisingly that T2 cells (T2 cells transfected with H-2Kb), being defective in the expression of TAP peptide transporters, still presented Sendai virus antigen on MHC class I molecules to CTL. LÄS MER

  7. 30. NK cells and missing self recognition : genetic control, mhc class i dependent education and potential use in cancer therapy

    Författare :Stina L Wickström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NK cells belong to the innate immune system and are important in the defense against virus infections and malignant cells. They mediate their effector functions via release of cytotoxic granules and by cytokine production which can influence the status of other (immune) cells. LÄS MER