Sökning: "HLA"

Visar resultat 1 - 5 av 386 avhandlingar innehållade ordet HLA.

  1. 1. Multiplex HLA-DR-DQ genotyping for genetic epidemiology and clinical risk assessment

    Detta är en avhandling från Malmö University. Faculty of Health and Society

    Författare :Ewa Lavant; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Sammanfattning : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. LÄS MER

  2. 2. Fault-tolerance in HLA-based distributed simulations

    Detta är en avhandling från Stockholm : KTH

    Författare :Martin Eklöf; Rassul Ayani; Gary Tan; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HLA; fault-tolerance; distributed simulations; federate; federation; TECHNOLOGY Information technology Computer engineering; TEKNIKVETENSKAP Informationsteknik Datorteknik;

    Sammanfattning : Successful integration of simulations within the Network-Based Defence (NBD), specifically use of simulations within Command and Control (C2) environments, enforces a number of requirements. Simulations must be reliable and be able to respond in a timely manner. Otherwise the commander will have no confidence in using simulation as a tool. LÄS MER

  3. 3. HLA and disease : studies in patients with arthritis, diabetes, inflammatory bowel diseases, kidney stone disease and myasthenia gravis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jan Säfwenberg; [1978]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 4. Human leukocyte antigen in sickness and in health Ankylosing spondylitis and HLA in Sweden

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jessika Nordin; Kerstin Lindblad-Toh; Jennifer Meadows; Matthew Webster; Alison Meynert; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Disease genetics; Ankylosing spondylitis; HLA typing; Imputation; Inference; Sex-stratified; HLA-B*27 independent; Association tests; Functional validation; Bioinformatics; Bioinformatik; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. LÄS MER

  5. 5. Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort

    Detta är en avhandling från Diabetes and Celiac Disease Unit

    Författare :Sara Björck; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mineral density; inflammation; cytokine; screening; HLA; tissue transglutaminase antibody; children; Celiac disease; vitamin D; parathyroid hormone;

    Sammanfattning : Objectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. LÄS MER