Sökning: "mPGES-1"
Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet mPGES-1.
1. mPGES-1 and the PGE2 pathway in arthritis
Sammanfattning : Prostaglandins are a group of lipid mediators derived from essential fatty acids that act on cells in close proximity of their synthesis. Prostaglandins are produced in a cell specific manner by a variety of cells in response to physiological or pathological stimulation. LÄS MER
2. Prostaglandin E2 in Brain-mediated Illness Responses
Sammanfattning : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. LÄS MER
3. mPGES-1 : a key regulator of fever and neonatal respiratory depression
Sammanfattning : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. LÄS MER
4. Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
Sammanfattning : Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and the microsomal prostaglandin E synthase 1 (mPGES-1). LÄS MER
5. Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer
Sammanfattning : Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E synthase-1 (mPGES-1). LÄS MER