Sökning: "cannabis som läkemedel"

Hittade 3 avhandlingar innehållade orden cannabis som läkemedel.

  1. 1. Synthesis of bioactive natural products and analogues

    Författare :Dan Killander; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SAR; natural product; total synthesis; benzochromene; fluorene; cannabinoid; statin; TRPA1; TSLP; antiprotozoal; nociception; asthma; inflammation;

    Sammanfattning : Natural products have until recently provided the only remedy for treatment of diseases. The development of modern chemistry in the last centuries has opened the door for tapping into the chemical diversity found in nature. Synthetic natural products, together with analogues, are an important piece in the puzzle towards curing many ailments. LÄS MER

  3. 2. Distribution and function of TRP ion channels in primary sensory neurons

    Författare :Helena Sturesson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; histokemi; cytokemi; vävnadskultur; Neurology; neuropsychology; neurophysiology; Neurologi; tissue culture; histochemistry; cytochemistry; Histology; Skin; Immunohistochemistry; Cannabinoid receptor 1 CB1 ; Pain; Primary sensory neurons; TRP ion channels; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Histologi;

    Sammanfattning : It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. LÄS MER

  4. 3. Gating and modulation mechanism of voltage gated sodium channels

    Författare :Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

    Sammanfattning : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. LÄS MER