Sökning: "antiprotozoal"
Hittade 4 avhandlingar innehållade ordet antiprotozoal.
1. Synthesis of bioactive natural products and analogues
Sammanfattning : Natural products have until recently provided the only remedy for treatment of diseases. The development of modern chemistry in the last centuries has opened the door for tapping into the chemical diversity found in nature. Synthetic natural products, together with analogues, are an important piece in the puzzle towards curing many ailments. LÄS MER
2. Secondary Metabolites from Mozambican Plants
Sammanfattning : Products derived from different natural sources have been used for thousands of years by human beings for their everyday needs. Out of these natural sources, plants were the most affordable. Plant-derived products were used for shelter, food, and as medicines. LÄS MER
3. Development of therapeutic strategies for quiescent tumor cell populations
Sammanfattning : Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs and as drug discovery tools. LÄS MER
4. New preclinical strategies for characterization and development of anticancer drugs
Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER