Sökning: "Philip Biggin"

Hittade 3 avhandlingar innehållade orden Philip Biggin.

1. 1. Gating and modulation mechanism of voltage gated sodium channels

   Författare :Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

   Sammanfattning : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. LÄS MER

3. 2. The molecular basis for substrate recognition and gating in sugar transporters

   Författare :Sarah McComas; David Drew; Philip Biggin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; membrane transport; sugar transporter; simulations; lipids; antimalarial drugs; biokemi; Biochemistry;

   Sammanfattning : Sugar is a vital sustenance for most forms of life. For a cell to take up sugar, specialized transport proteins embedded into the membrane bilayer known as sugar porters, are required. LÄS MER

4. 3. Elucidating the Gating Mechanism of Cys-Loop Receptors

   Författare :Özge Yoluk; Erik Lindahl; Philip Biggin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channel; gating; simulation; molecular dynamics; receptor; cys-loop; modelling; Teoretisk kemi och biologi; Theoretical Chemistry and Biology; Biological Physics; Biologisk fysik;

   Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER