Sökning: "basic assumptions"

Visar resultat 1 - 5 av 94 avhandlingar innehållade orden basic assumptions.

  1. 1. The Psychology of Worldviews: Toward a Non-Reductive Science of Personality

    Detta är en avhandling från Lund University

    Författare :Artur Nilsson; Lunds universitet.; Lund University.; [2013]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Worldview; personality; philosophy of life; weltanshauung; life view; ideology; existentialism; non-reductive; humanism; normativism; polarity theory; political psychology; philosophy of science; philosophy of psychology; philosophical orientation; basic assumptions; presuppositions; core assumptions; personal constructs; theoretical psychology; integrative framework; personalism;

    Sammanfattning : Popular Abstract in Swedish Personer drivs inte enbart av djuriska instinkter, utan de är även språkliga och existentiellt medvetna varelser, vars upplevelser och handlingar är fyllda av subjektiv mening. Att förstå en människa som en person är att förstå honom eller henne som ett rationellt system som har viljor, rädslor, förhoppningar, trosföreställningar, och andra sätt att ge sin värld mening, och inte bara som ett mekaniskt system av som styrs av samma orsaker som andra djur. LÄS MER

  2. 2. Anatomical, neurochemical and behavioural consequences of immunotoxin lesions of the basal forebrain cholinergic system

    Detta är en avhandling från Lund University

    Författare :Giampiero Leanza; Lunds universitet.; Lund University.; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural transplantation; reinnervation; axon growth; functional sparing; memory; learning; cortex; hippocampus; immunolesion; acetylcholine; basal forebrain; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Physiology; Fysiologi;

    Sammanfattning : The cholinergic hypothesis of geriatric memory dysfunction suggests that the learning and memory deficits representing the cardinal symptoms of dementia in the aged and in patients suffering from Alzheimer's disease may be attributable to a decline in the function of the cholinergic projection systems of the basal forebrain. Although many studies have addressed the issue of a causal relationship between cholinergic hypofunction and cognitive disturbance, analyses of the functional role of the basal forebrain cholinergic neuronal systems in the brain have so far been hampered by the lack of an efficient and specific cholinergic neurotoxin. LÄS MER

  3. 3. Pharmacometric evaluation and improvement of models and study designs - applied in diabetes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Moustafa M. A. Ibrahim; Uppsala universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Pharmacometric models are increasingly used to improve the efficiency of the drug development process and increase our understanding of the studied underlying pathophysiological system. These models require assumptions for handling different types of data and the different model components, and the appropriateness of such assumptions must be carefully inspected for unbiased conclusions. LÄS MER

  4. 4. Applied Adaptive Optimal Design and Novel Optimization Algorithms for Practical Use

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Eric Strömberg; Uppsala universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nonlinear Mixed Effects Models; Pharmacometrics; Fisher Information Matrix; Approximation; Optimality Criterion; Parallelization; Model Based Adaptive Optimal Design; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : The costs of developing new pharmaceuticals have increased dramatically during the past decades. Contributing to these increased expenses are the increasingly extensive and more complex clinical trials required to generate sufficient evidence regarding the safety and efficacy of the drugs. LÄS MER

  5. 5. Methodological studies on non-linear mixed effects model building

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :E. Niclas Jonsson; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. LÄS MER