Sökning: "Voltage gated sodium channels"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Voltage gated sodium channels.

  1. 1. Gating and modulation mechanism of voltage gated sodium channels

    Författare :Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

    Sammanfattning : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. LÄS MER

  3. 2. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease

    Författare :Michelle Nilsson; Antonios Pantazis; Fredrik Elinder; Henry M. Colecraft; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. LÄS MER

  4. 3. Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels

    Författare :Malin Silverå Ejneby; Fredrik Elinder; Johan Brask; Dirk Snyders; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Voltage-gated ion channels are pore-forming membrane proteins that open or close their gates when the voltage across the membrane is changed. They underlie the electrical activity that enables the heart to pump blood and the brain to receive and send signals. LÄS MER

  5. 4. Role of potassium channels in regulating neuronal activity

    Författare :Göran Klement; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

    Sammanfattning : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. LÄS MER

  7. 5. Ion channels in drug discovery : focus on biological assays

    Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER