Avancerad sökning

Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

   Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

   Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER

3. 2. Models of chemical bonding : Representations Used in School Textbooks and by Teachers and their Relation to Students´Difficulties in Understanding

   Författare :Anna Bergqvist; Michal Drechsler; Shu-Nu Chang Rundgren; Pernilla Nilsson; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pedagogical content knowledge; chemical bonding; textbook analysis; students learning difficulties; models in science education; Kemi; Chemistry;

   Sammanfattning : This thesis focuses on how school textbooks and teachers present models of chemical bonding in upper secondary schools in Sweden. In science, as well as in science education, models play a central role, but research has shown that they often are difficult for students to understand. LÄS MER

4. 3. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

   Författare :Niklas Lindegårdh; Karin Markides; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. LÄS MER

5. 4. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

   Författare :Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. LÄS MER

7. 5. Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids

   Författare :Daniel Blessborn; Yngve Bergqvist; Anders Helander; Högskolan Dalarna; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Malaria; Chloroquine; Quinine; Sulfadoxine; Pyrimethamine; Mefloquine; Lumefantrine; Amodiaquine; Pyronaridine; Proguanil; Atovaquone; Sampling paper; Dried blood spots; Capillary blood; Antimalarial drugs; Solid-phase extraction; Liquid chromatography.; Chemistry;

   Sammanfattning : The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. LÄS MER