Sökning: "DNA repair enzyme"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden DNA repair enzyme.
1. AtZDP, a Plant 3' DNA Phosphatase, Involved in DNA Repair
Sammanfattning : DNA bases can be modified by endogenous agents (e.g. oxidized by products of respiration and photosynthesis or methylated by gene silencing processes) as well as by environmental agents (e.g. LÄS MER
2. Oxidative damage and the DNA glycosylase MutYH
Sammanfattning : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. LÄS MER
3. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1
Sammanfattning : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. LÄS MER
4. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity
Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER
5. Ribonucleotide reductase and DNA damage
Sammanfattning : A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. LÄS MER