Sökning: "zidovudine"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet zidovudine.

  1. 1. Drug Analysis : Bioanalytical Method Development and Validation

    Författare :Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER

  3. 2. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER

  4. 3. Primary HIV-1 infection : diagnostic, prognostic, and therapeutic aspects

    Författare :Stefan Lindbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :primary HIV- I infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment; primary HIV-1 infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment;

    Sammanfattning : Primary HIV-1 infection (PHI) is usually defined as a mononucleosis-like illness associated with seroconversion to HIV. In earlier studies using 1st generation antibody tests, the duration of the 'window period' from infection to detection of specific HIV-antibodies, could be 2 to 3 months, or longer. LÄS MER

  5. 4. In vivo and in vitro models for determination of antiviral activity and resistance

    Författare :Ewa Ljungdahl Ståhle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. LÄS MER

  7. 5. Influencing HIV treatment success in India : do mobile phones really work?

    Författare :Anita Shet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV;

    Sammanfattning : Background: Sustaining treatment adherence and long-term virological suppression is a global health challenge in HIV management. Mobile phone-based interventions are increasingly harnessed to enhance medication adherence in HIV infection, although supporting evidence for implementation is limited by lack of robust efficacy trials in settings such as India. LÄS MER