Sökning: "piperaquine"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet piperaquine.

  1. 1. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Författare :Joel Tärning; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Sammanfattning : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. LÄS MER

  3. 2. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics

    Författare :Mohd Yusmaidie Aziz; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioanalysis; Pharmacokinetics; Piperaquine; Malaria;

    Sammanfattning : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. LÄS MER

  4. 3. Drug Analysis : Bioanalytical Method Development and Validation

    Författare :Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER

  5. 4. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

    Författare :Niklas Lindegårdh; Karin Markides; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. LÄS MER

  7. 5. Development of field-adapted analytical methods for the determination of new antimalarial drugs in biological fluids

    Författare :Niklas Lindegårdh; Högskolan Dalarna; []
    Nyckelord :LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots;

    Sammanfattning : .... LÄS MER