Sökning: "antibacterial agents"

Visar resultat 6 - 10 av 37 avhandlingar innehållade orden antibacterial agents.

  1. 6. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

    Författare :Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; Umeå universitet; []
    Nyckelord :Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. LÄS MER

  3. 7. Antimicrobial materials from cellulose using environmentally friendly techniques

    Författare :Anna Ottenhall; Monica Ek; Josefin Illergård; Orlando Rojas; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Antibacterial; antifungal; cellulosic; mold; bacteria; biobased; bio-based; renewable; insulation; packaging; water treatment; water purification; paper filter; paper; membrane; Antibakteriell; fungicid; mögel; antimögel; pappersfilter; vattenrening; membran; papper; bakterier; cellulosa; förpackning; isolering; förnyelsebar; biobaserade; nya material; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : The transition to a more biobased society introduces both new opportunities and new challenges as we replace nonrenewable materials with renewable alternatives. One important challenge will be to control microbial growth on materials, both to protect the materials from biological degradation and to prevent the spread of infections and toxins that can cause illness. LÄS MER

  4. 8. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

    Författare :Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

    Sammanfattning : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. LÄS MER

  5. 9. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors

    Författare :Tiago Bozzola; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic Acid; antibacterial agents; Medicinal Chemistry; Synthesis; uptake inhibitors;

    Sammanfattning : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. LÄS MER

  7. 10. Peptidomimetics based on ring-fused 2-pyridones : probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors

    Författare :Veronica Åberg; Fredrik Almqvist; Jan Kihlberg; Morten Grötli; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; peptidomimetic; antibacterial; pili; Escherichia coli; virulence; amyloid; Alzheimer’s.; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. LÄS MER