Sökning: "Translocation"
Visar resultat 21 - 25 av 496 avhandlingar innehållade ordet Translocation.
21. Integration and topology of membrane proteins
Sammanfattning : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. LÄS MER
22. Insertion studies of model transmembrane segments into bacterial and eukaryotic membranes
Sammanfattning : Cells are encapsulated by a biological membrane in order to separate the cell interior from the surrounding environment. Different lipids and proteins compose the membrane and present a semi-permeable barrier for the diffusion of ions and molecules across the lipid bilayer. LÄS MER
23. Membrane Interactions of Arginine-Rich Peptides for the Intracellular Delivery of Gene-Targeted Drugs
Sammanfattning : A major obstacle for the therapeutic use of e.g. oligonucleotides is their inherently poor cellular uptake. A recently discovered class of peptides, denoted cell-penetrating peptides, has been shown to traverse cell membranes, even when conjugated to oligonucleotides or even full-length proteins. LÄS MER
24. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence
Sammanfattning : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. LÄS MER
25. Virulence mechanisms of pathogenic Yersinia : aspects of type III secretion and twin arginine translocation
Sammanfattning : The pathogenic bacteria Yersinia pestis and Y. pseudotuberculosis are related to the degree where the former is considered a subspecies of the latter, and still they cause disease of little resemblance in humans. Y. pestis is the causative agent of lethal bubonic and pneumonic plague, while Y. LÄS MER
