Sökning: "Xbp1"

Hittade 4 avhandlingar innehållade ordet Xbp1.

  1. 1. Insertion studies of model transmembrane segments into bacterial and eukaryotic membranes

    Författare :Nina Schiller; Gunnar von Heijne; Paula Booth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ribosome; membrane integration; translocation; arrest peptide; SecM; Xbp1; Biochemistry; biokemi;

    Sammanfattning : Cells are encapsulated by a biological membrane in order to separate the cell interior from the surrounding environment. Different lipids and proteins compose the membrane and present a semi-permeable barrier for the diffusion of ions and molecules across the lipid bilayer. LÄS MER

  3. 2. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

    Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; Biochemistry; biokemi;

    Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER

  4. 3. Translational studies of drug-induced tumor cell death

    Författare :Maria Hägg Olofsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that induce tumor cell death. LÄS MER

  5. 4. Development of therapeutics for the treatment of diabetic brain complications

    Författare :Shiva Mansouri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type-2 diabetes (T2D) is characterized by hyperglycemia and hyperlipidemia, resulting in impaired insulin production and insulin resistance in peripheral tissues. Several studies have demonstrated an association between diabetes and central nervous system complications such as stroke and Alzheimer’s disease. LÄS MER