Sökning: "Roland Rosqvist"

Hittade 2 avhandlingar innehållade orden Roland Rosqvist.

  1. 1. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

    Författare :Margareta Aili; Roland Rosqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. LÄS MER

  3. 2. Timing and targeting of Type III secretion translocation of virulence effectors in Yersinia

    Författare :Sofie Ekestubbe; Åke Forsberg; Roland Rosqvist; Maria Fällman; Kurt Schesser; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; virulence; translocation; Yersinia pseudotuberculosis; LcrV; YopN; effector targeting; phagocytosis inhibition; YopH; in vivo infection;

    Sammanfattning : The Type III secretion system (T3SS) is an important virulence mechanism that allows pathogenic bacteria to translocate virulence effectors directly into the cytoplasm of eukaryotic host cells to manipulate the host cells in favor of the pathogen. Enteropathogenic Yersinia pseudotuberculosis use a T3SS to translocate effectors, Yops, that prevent phagocytosis by immune cells, and is largely dependent on it to establish and sustain an infection in the lymphoid tissues of a mammalian host. LÄS MER