Sökning: "type III secretion"

Visar resultat 1 - 5 av 143 avhandlingar innehållade orden type III secretion.

  1. 1. Chemical attenuation of bacterial virulence small molecule inhibitors of type III secretion

    Detta är en avhandling från Umeå : Kemi

    Författare :Anna Kauppi; Umeå universitet.; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER

  2. 2. Virulence mechanisms of pathogenic Yersinia aspects of type III secretion and twin arginine translocation

    Detta är en avhandling från Umeå : Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)

    Författare :Moa Lavander; Umeå universitet.; [2005]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia pestis; Yersinia pseudotuberculosis; bacterial pathogenesis; type III secretion; twin arginine translocation; virulence mechanisms; YscU; YscP; YscF; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The pathogenic bacteria Yersinia pestis and Y. pseudotuberculosis are related to the degree where the former is considered a subspecies of the latter, and still they cause disease of little resemblance in humans. Y. pestis is the causative agent of lethal bubonic and pneumonic plague, while Y. LÄS MER

  3. 3. Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa

    Detta är en avhandling från Umeå : Molekylärbiologi (Teknisk-naturvetenskaplig fakultet)

    Författare :Charlotta Sundin; Umeå universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Pseudomonas aeruginosa; type III secretion system; ExoS; ExoT; PcrV; PcrG; PopB; PopD; PopN; type IV pili; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : .... LÄS MER

  4. 4. Multiple functions of YopN in the Yersinia pseudotuberculosis type III secretion system from regulation to in vivo infection

    Detta är en avhandling från Umeå : Umeå University

    Författare :Sarp Bamyaci; Umeå universitet.; Umeå universitet.; Umeå universitet.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; Yersinia; YopN; virulence; phagocytosis; mouse infection; secretion kinetics;

    Sammanfattning : The type 3 secretion systems (T3SSs) are virulence mechanisms used by various Gram-negative bacteria to overcome the host immunity. They are often target-cell contact induced and activated. Activation results in targeting of virulence effector substrates into host cells. LÄS MER

  5. 5. Small Molecules as Tools in Biological Chemistry Effects of Synthetic and Natural Products on the Type III Secretion System

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Caroline E. Zetterström; Umeå universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER