Sökning: "Sec61"

Hittade 5 avhandlingar innehållade ordet Sec61.

1. 1. Integration and topology of membrane proteins

   Författare :Carolina Boekel; Gunnar von Heijne; IngMarie Nilsson; Stephen High; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insertion; Sec61; translocation; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. LÄS MER

3. 2. Membrane Protein Biogenesis in Saccharomyces cerevisiae

   Författare :Johannes Reithinger; Gunnar von Heijne; Richard Zimmermann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : Membranes are hydrophobic barriers that define the outer boundaries and internal compartments of living cells. Membrane proteins are the gates in these barriers, and they perform vital functions in the highly regulated transport of matter and information across membranes. LÄS MER

4. 3. Integration of Transmembrane Helices into the Endoplasmic Reticulum

   Författare :Tara Hessa; Gunnar von Heijne; James Bowie; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

   Sammanfattning : Membrane proteins reside in cell and organelle membranes. They play significant roles in many processes vital to living cells. Receptors and ion channels are examples of membrane proteins that regulate the physiological state of the cell and are attractive targets for drug development. LÄS MER

5. 4. What’s in? What’s out? And how did it get there? : Studies on topologies and insertion of membrane proteins

   Författare :Marie Österberg; Gunnar von Heijne; Peter Rehling; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; yeast; mitochondria; TIM23; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Because of their hydrophobic and hydrophilic nature and the need for a lipid bilayer for retaining the native structure, membrane proteins are hard to study. Nevertheless, they are important, as many of our diseases are related to membrane proteins and around 60% of the different pharmaceutical drugs are directed against a membrane proteins [1]. LÄS MER

7. 5. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

   Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; Biochemistry; biokemi;

   Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER