Sökning: "Substituent effects"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden Substituent effects.

  1. 16. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Författare :Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER

  3. 17. Exploring Novel Catalytic Chalcogenide Antioxidants

    Författare :Henrik Johansson; Lars Engman; Helena Grennberg; Troels Skrydstrup; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antioxidant; tellurium; selenium; catalytic; toxicity; ROS; neutrophil; glutathione peroxidase mimic; macrophage.; Organic chemistry; Organisk kemi; Kemi med inriktning mot organisk kemi; Chemistry with specialization in Organic Chemistry;

    Sammanfattning : This thesis is concerned with the synthesis and evaluation of regenerable chalcogen containing antioxidants. Variously substituted 2,3-dihydrobenzo[b]selenophene-5-ol antioxidants were evaluated in order to gain information about structure/reactivity-relationships. LÄS MER

  4. 18. Design and Synthesis of Enzyme Inhibitors Against Infectious Diseases : Targeting Hepatitis C Virus NS3 Protease and Mycobacterium tuberculosis Ribonucleotide Reductase

    Författare :Johan Gising; Mats Larhed; Anders Karlén; Victor Snieckus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Infectious diseases, including hepatitis C and tuberculosis, claim the lives of over 15 million people each year. Hepatitis C is caused by the hepatitis C virus (HCV) which infects the liver and can ultimately result in liver transplantation. HCV is very adaptive as a result of its high mutation rate. LÄS MER

  5. 19. Ultrafast Photo-induced Reaction Dynamics of Small Molecules

    Författare :Malin Kadi; Jan Davidsson; Eva Åkesson; Sören Keiding; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; pump-probe spectroscopy; reaction dynamics; photodissociation; aryl halides; spin-orbit coupling; ab initio calculations; molecular dynamics; vibrational wavepackets; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : The main focus of this thesis is the investigation of the dissociation dynamics of aryl halides using femtosecond pump-probe spectroscopy. In the monohalogenated aryl halides, iodo-, bromo- and chlorobenzene, the rate of dissociation following excitation at 266 nm in the gas phase increased with increasing mass of the halogen atom. LÄS MER

  7. 20. Application of chemical oxidation processes for the removal of pharmaceuticals in biologically treated wastewater

    Författare :Gerly Hey; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : The discharge of effluents from wastewater treatment plants (WWTPs) is considered to be the major source of residual pharmaceuticals frequently found in aquatic environments. The complex nature of such compounds tends to make conventional biological treatments aimed at their removal ineffective. LÄS MER