Sökning: "Johan Gising"

Hittade 2 avhandlingar innehållade orden Johan Gising.

1. 1. Design and Synthesis of Enzyme Inhibitors Against Infectious Diseases : Targeting Hepatitis C Virus NS3 Protease and Mycobacterium tuberculosis Ribonucleotide Reductase

   Författare :Johan Gising; Mats Larhed; Anders Karlén; Victor Snieckus; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Infectious diseases, including hepatitis C and tuberculosis, claim the lives of over 15 million people each year. Hepatitis C is caused by the hepatitis C virus (HCV) which infects the liver and can ultimately result in liver transplantation. HCV is very adaptive as a result of its high mutation rate. LÄS MER

3. 2. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

   Författare :Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER