Sökning: "quinoline 3-carboxamides"
Hittade 3 avhandlingar innehållade orden quinoline 3-carboxamides.
1. Effect of quinoline-3-carboxamides on myeloid cells in inflammation and cancer
Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. LÄS MER
2. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species
Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER
3. S100A9 in inflammatory disease: a potential target for amelioration
Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. LÄS MER