Sökning: "vaccine carriers"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden vaccine carriers.

  1. 1. Liposomes for mucosal vaccine delivery: physicochemical characterization and biological application

    Författare :Karin Norling; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanoparticles; vaccine carriers; antigen presentation; dendritic cells; surface plasmon resonance; flow cytometry; liposomes; cellular uptake; fluorescence microscopy; influenza;

    Sammanfattning : Liposomes are attractive vaccine carriers due to their potential to act as adjuvants, and to the fact that their composition and characteristics are virtually endlessly customizable. However, the precise physicochemical profile of an ideal carrier liposome for mucosal vaccines is still widely unknown, and how different properties affect key steps in the acquisition of protective immunity remains to be elucidated. LÄS MER

  3. 2. Studying the influence of the physicochemical properties of lipid nanoparticles for mucosal vaccine delivery

    Författare :Karin Norling; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; nanoparticles; CTA1-DD; liposomes; dendritic cells; lipodisks; antigen presentation; flow cytometry; vaccine carriers; TIRF microscopy;

    Sammanfattning : Lipid-based nanoparticles have attracted attention as promising pharmaceutical carriers. Reports of them having inherent adjuvant properties make them particularly interesting as vaccine vectors; however, the physicochemical profile of an ideal nanoparticle for mucosal vaccine delivery remains unknown. LÄS MER

  4. 3. Immunogenicity and protective potential of Protein D of Haemophilus influenzae against H. influenzae infection

    Författare :Mustafa Akkoyunlu; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bactericidal assay; mucosal immunity; otitis media; vaccine; H. influenzae; protein D; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Both Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) are important human pathogens causing invasive and mucosal infections. Currently there are number of vaccines available against Hib infections. LÄS MER

  5. 4. Mass spectrometry-based proteomic strategies applied to Helicobacter pylori. A Search for candidate vaccine antigens

    Författare :Elisabet Carlsohn; Göteborgs universitet; []
    Nyckelord :proteomics; mass spectrometry; Helicobacter pylori; membrane proteins; nano-liquid chromatography; subcellular fractionation;

    Sammanfattning : This thesis describes the development and refinement of proteomic strategies and the application of these on the human gastric pathogen H. pylori. The purpose was to identify proteins, and in particular membrane proteins, as potential targets for vaccine development. LÄS MER

  7. 5. Vaccination against drug-resistant HIV

    Författare :Andreas Boberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; DNA vaccine; drug-resistance;

    Sammanfattning : As the use of antiretroviral drug treatment increases worldwide, development of drug resistant HIV phenotypes is expected to increase. The frequency of drug- or multi-drug resistant virus transmitted in primary infections will consequently be more abundant. Logical vaccine targets in drug-resistant strains are reverse transcriptase and protease. LÄS MER