Sökning: "Reactive Metabolite"

Visar resultat 6 - 10 av 29 avhandlingar innehållade orden Reactive Metabolite.

  1. 6. New approaches for synthesis and analysis of adducts to N-terminal valine in hemoglobin from isocyanates, aldehydes, methyl vinyl ketone and diepoxybutane

    Författare :Ronnie Davies; Margareta Törnqvist; Leif Kronberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbamoylation; modified-Edman procedure; 5- hydroxymethyl furfural; MISPE; biomarkers; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

    Sammanfattning : Human exposure to harmful compounds in the environment, from intake via food, occupational exposures or other sources, could have health implications. Exposure to reactive compounds/metabolites can be identified and quantified as hemoglobin (Hb) adducts by mass spectrometry. LÄS MER

  3. 7. Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis : Studies on lymphocytes, inflammatory markers and magnetic resonance spectroscopy

    Författare :Johan Mellergård; Magnus Vrethem; Jan Ernerudh; Charlotte Dahle; Sten Fredrikson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS), and a frequent cause of neurological disability among young adults. In addition to focal inflammatory demyelinated lesions, diffuse white matter pathology as well as a neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. LÄS MER

  4. 8. Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques

    Författare :Annica Tevell Åberg; Mikael Hedeland; Ulf Bondesson; Mario Thevis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. LÄS MER

  5. 9. A qualitative and quantitative study of nitrotyrosine using mass spectrometry and immunochemistry

    Författare :Ann-Sofi Söderling; Göteborgs universitet; []
    Nyckelord :mass spectrometry; oxidative stress; nitrotyrosine; nitric oxide; protein modification;

    Sammanfattning : Background: Reactive oxygen (ROS), and nitrogen (RNS) species are formed during normal metabolism and in higher concentration in pathological conditions. They may cause cellular damage when the antioxidant defence is unable to balance the production of oxidants. LÄS MER

  7. 10. Selenium cytotoxicity in cancer

    Författare :Marita Wallenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential trace element, present in the 21st amino acid selenocysteine, which is specifically incorporated into selenoproteins. Today, there are 25 identified selenoproteins in humans, whereof many comprises redox active functions to uphold the intracellular redox balance. LÄS MER