Sökning: "Proteasome activation"
Visar resultat 1 - 5 av 55 avhandlingar innehållade orden Proteasome activation.
1. Functional analysis of the proteasome in eukaryotic organisms
Sammanfattning : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. LÄS MER
2. Investigating the activation and regulation of the proteasome : an essential proteolytic complex
Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER
3. Tripeptidyl-Peptidase II : Structure, Function and Gene Regulation
Sammanfattning : The protein degradation process is of vital importance for the cell to maintain cellular functions. An important enzyme in this process is the multimeric tripeptidyl-peptidase II (TPP II). It removes tripeptides from a free N-terminus of the substrates. LÄS MER
4. Protein Quality Control at the Inner Nuclear Membrane – The Asi complex in Saccharomyces cerevisiae
Sammanfattning : The nuclear envelope is a barrier comprised of outer and inner membranes that separate the cytoplasm from the nucleoplasm. The outer (ONM) and inner (INM) membranes have different physical characteristics and protein compositions. LÄS MER
5. Pancreatic Cancer. Experimental and Clinical Studies
Sammanfattning : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. LÄS MER