Sökning: "Lifespan extension"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Lifespan extension.

  1. 1. Vertical Extension of Buildings

    Författare :Rikard Nilsson; Avdelningen för Byggproduktion; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Sustainability; Densification; energy-efficient renovation; Urban Development; Stakeholder;

    Sammanfattning : Many policy targets have been developed with the aim of reaching a more sustainable development; more specifically, thestudied policies target energy use and urban growth. For example, by 2050 the aim is that the European Union will havereduced its greenhouse emissions by 90%. LÄS MER

  3. 2. Functional analysis of the proteasome in eukaryotic organisms

    Författare :Marianthi Sakellari; Efstathios S. Gonos; Allan Sirsjö; Richard G. A. Faragher; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteasome; Proteasome activation; Protein synthesis inhibition; Hsp70; Hsp90; Proteostasis; Aging; Alzheimer’s disease; Caenorhabditis elegans; Lifespan extension; SKN-1;

    Sammanfattning : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. LÄS MER

  4. 3. Peroxiredoxins in Redox Signaling and Aging

    Författare :Friederike Roger; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Peroxiredoxin; Redox Signaling; Caloric restriction; light sensing;

    Sammanfattning : Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. LÄS MER

  5. 4. Age-specific trade-offs in life-history evolution

    Författare :Martyna K. Zwoinska; Alexei Maklakov; Marjo Saastamoinen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; life history; trade-off; learning; aging; sex differences; dispersal; Caenorhabditis; Drosophila; Biologi med inriktning mot zooekologi; Biology with specialization in Animal Ecology;

    Sammanfattning : Trade-offs prevent selection from driving all fitness-enhancing traits towards values that would maximize fitness. Life-history trade-offs, such as the one between survival and reproduction are well-studied, yet trade-offs can also involve behavioural or cognitive traits. LÄS MER

  7. 5. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

    Författare :Sarah Hanzén; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

    Sammanfattning : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. LÄS MER