Avancerad sökning

Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Tissue transglutaminase autoantibodies in childhood celiac disease

    Författare :Daniel Agardh; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; transplantation; villous atrophy; T cells; serological marker; screening; intestinal mucosa; children; celiac disease; CD25; CD8; CD4; autoantibodies; B cells; gluten-free diet; autoimmunity;

    Sammanfattning : Celiac disease is a prevalent small bowel disease in children caused by permanent intolerance against gliadin, which is the alcohol-soluble fraction of the cereal protein gluten in wheat, rye and barley. Celiac disease is characterized by an inflammatory infiltrate of CD4+ T lymphocytes in the intestinal mucosa leading to damage of villous structure and loss of absorptive surface. LÄS MER

  3. 2. Aspects of ZnT8 autoimmunity in childhood type 1 diabetes

    Författare :Cecilia K Andersson; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Zinc transporter; ZnT8 autoantibodies; HLA; islet cell autoantibodies; GAD65 autoantibodies; IA-2 autoantibodies; insulin autoantibodies; glucose tolerance;

    Sammanfattning : Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. LÄS MER

  4. 3. Peripheral neuropathy in type 1 and type 2 diabetes – screening of vibrotactile sense and proteomics in human nerve biopsies

    Författare :Erik Ising; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1 diabetes; type 2 diabetes; peripheral neuropathy; vibrotactile sense; multi-frequency vibrometry; nerve biopsy; proteomic;

    Sammanfattning : .... LÄS MER

  5. 4. Autoimmunogenetic Aspects of Vaccine-induced Narcolepsy. As part of the AMINA - Autoimmune Multiple Sclerosis and Narcolepsy Study

    Författare :Alexander Lind; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Narcolepsy type 1 (NT1) is a neurological sleep disorder. The biological cause is the degeneration of hypocretin neurons located in the hypothalamus. It has been suggested that NT1 has an autoimmune pathogenesis, as in most patients, the Human Leukocyte Antigen (HLA)-DQB1*06:02:01 is present. LÄS MER

  7. 5. Preventing the Predictable. Type 1 diabetes in children: Risk factors and impact of participation in prospective follow-up

    Författare :Markus Lundgren; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Aim: The aim of this thesis was to identify risk factors for type 1 diabetes in children, evaluate the effects of participation in prospective follow-up and the safety of immune tolerance treatment with GAD-Alum in children with islet autoimmunity.Methods: Subjects from the Swedish DiPiS cohort were studied regarding risk factors, cord blood islet autoantibodies and the effects of early severe life events. LÄS MER