Sökning: "Omeprazole"

Visar resultat 21 - 25 av 37 avhandlingar innehållade ordet Omeprazole.

  1. 21. CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions

    Författare :Staffan Rosenborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20% of all drugs. All CYP2C enzymes are polymorphic, i.e. LÄS MER

  3. 22. Pharmaceutical and mutational interference with virulence of Salmonella enterica serovar typhimurium

    Författare :Aurel Negrea; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Within the species Salmonella enterica are a diverse range of bacteria that can cause illness in humans and many animals. Salmonellae are extremely versatile and can adapt to a variety of environments and hosts. Typhoid and paratyphoid fever, caused by human-restricted S. enterica serovars Typhi and Paratyphi are common in the developing world. LÄS MER

  4. 23. Pharmacokinetics, drug metabolism and clinical effects of the antimalarial artemisinin : Time-dependencies and modeling aspects

    Författare :Ulrika Sigrid Helena Svensson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The mechanism behind artemisinin time-dependent bioavailability was investigated using a rat in-situ single-pass jejunal perfusion technique. The consequence for drug combination therapy was studied in healthy volunteers and in patients with Plasmodium falciparum. LÄS MER

  5. 24. Enantioseparation of drugs and related compounds using chiral mobile phase additives

    Författare :Ngoc Hang Huynh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Neutral and anionic chiral mobile phase additives have been employed to separate enantiomers of drugs and related compounds using aqueous buffer solution and hydro-organic solvent mixtures as mobile phases.Ester derivatives of tartaric acid, e. g. LÄS MER

  7. 25. Physiological and pathophysiological regulation of ECL-cell activity

    Författare :Maria Lundgren; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Pharmacological sciences; pharmacognosy; Gastroenterologi; endothelin; gastrin; ischemia-reperfusion; Physiology; Fysiologi; Gastro-enterology; pancreastatin; histamine; microdialysis; ECL-cell; stomach; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They produce and secrete histamine and chromogranin A-derived peptides in response to circulating gastrin. Mobilized histamine stimulates acid secretion from adjascent parietal cells. LÄS MER