Sökning: "Omeprazole"

Visar resultat 6 - 10 av 37 avhandlingar innehållade ordet Omeprazole.

1. 6. Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients

   Författare :Hyung-Keun Roh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; phenotype; genotype; CYP2D6; CYP2C 19; Korean; haloperidol; risperidone; omeprazole; gastric pH; gastrin; schizophrenia; patient.;

   Sammanfattning : This thesis aimed to investigate the relationship between pheno- and genotype of two drugmetabolizing enzymes CYP2D6 and CYYP2C19 in Koreans. Population studies were conducted in healthy volunteers to obtain basic information on these two enzymes. LÄS MER

3. 7. Metabolic drug interactions in man : methodological aspects on in vivo studies

   Författare :Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

   Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER

4. 8. CYP2C19 catalyzed drug metabolism in different populations

   Författare :Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

   Sammanfattning : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. LÄS MER

5. 9. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

   Författare :Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

   Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER

7. 10. Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene

   Författare :Maria Backlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AhR; omeprazole; primaquine; CYP1A1; ligand-independent activation; ligandbinding domain; protein tyrosine kinase; c-src kinase;

   Sammanfattning : The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that is responsible for the activation of several response genes, of which the best characterised is the CYP1A1 gene. The prototype high affinity ligand for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). LÄS MER