Sökning: "Molecular neurobiology"

Visar resultat 1 - 5 av 95 avhandlingar innehållade orden Molecular neurobiology.

  1. 1. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

    Författare :Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER

  3. 2. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models

    Författare :Henrik Gezelius; Klas Kullander; Ted Ebendal; Martyn Goulding; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetyl choline; central nervous system; central pattern generator; Cre recombinase; development; genetic screen; glutamate; interneuron; motor neuron; mouse; mouse genetics; movement; network; neuronal network; nicotinic receptors; physiology; Renshaw cell; rhythm; spinal cord; transmitter; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi; Neurophysiology; Neurofysiologi; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. LÄS MER

  4. 3. Positron Emission Tomography (PET) Studies in Anxiety Disorders

    Författare :Åsa Michelgård Palmquist; Mats Fredrikson; Lars von Knorring; Hans Ågren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; amygdala; fear; anxiety; anxiety disorders; specific phobia; social phobia; posttraumatic stress disorder; PTSD; regional cerebral blood flow; rCBF; substance P; SP; neurokinin 1 receptor; NK1; GR205171; STAI-S; Psychiatry; Psykiatri; Neurobiology; Neurobiologi; Neuroscience; Neurovetenskap; Experimental brain research; Experimentell hjärnforskning; Molecular neurobiology; Molekylär neurobiologi; Radiation biology; Strålningsbiologi; Neurobiology; Neurobiologi; Neurobiology; Neurobiologi;

    Sammanfattning : Anxiety disorders are very common and the primary feature is abnormal or inappropriate anxiety. Fear and anxiety is often mediated by the amygdala, a brain structure rich in substance P (SP) and neurokinin 1 (NK1) receptors. LÄS MER

  5. 4. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

    Författare :Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

    Sammanfattning : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. LÄS MER

  7. 5. Neural Control of Movement : Motor Neuron Subtypes, Proprioception and Recurrent Inhibition

    Författare :Anders Enjin; Klas Kullander; Samuel L. Pfaff; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; motor neuron; proprioception; recurrent inhibition; molecular marker; Ia afferent; development; transgenic mice; Renshaw cell; Neurobiology; Neurobiologi; Neuroscience; Neurovetenskap;

    Sammanfattning : Movement is central for life, and all animals depend on accurate regulation of movement for purposeful behavior. There is great diversity of movements, ranging between simple and vital breathing movements to minute and subtle movements of the face used to communicate emotions. LÄS MER