Sökning: "Neurosciences"

Visar resultat 11 - 15 av 671 avhandlingar innehållade ordet Neurosciences.

1. 11. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

   Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER

3. 12. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects

   Författare :Sara af Bjerkén; Ingrid Strömberg; Kathy Steece-Collier; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; GDNF; L-DOPA; L-DOPA induced dyskinesia; Neurobiology; Neurobiologi;

   Sammanfattning : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. LÄS MER

4. 13. Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis

   Författare :Simon Agerskov; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; idiopathic normal pressure hydrocephalus; MRI; biomarkers; prediction;

   Sammanfattning : Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement in up to 80% of patients. LÄS MER

5. 14. Development of highly biocompatible neuro-electronic interfaces towards monitoring authentic neuronal signaling in the brain

   Författare :Johan Agorelius; NanoLund: Centre for Nanoscience; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; BMI; brain machine interface; Neuro-electronic interface; neurophysiology; brain computer interface; biocompatibility; biocompatible neural interface; neural interface; histology; electrophysiology;

   Sammanfattning : Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with the tissue and that can remain positionally stablewith respect to the neurons, despite the continuous micromotions in the brain. LÄS MER

7. 15. The Biophysics of Na+,K+-ATPase in neuronal health and disease

   Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

   Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER