Sökning: "NONMEM"

Visar resultat 16 - 20 av 48 avhandlingar innehållade ordet NONMEM.

1. 16. Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

   Författare :Maria C. Kjellsson; Mats O. Karlsson; Siv Jönsson; Gordon Graham; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacodynamics; Categorical data; Markov model; Modelling; NONMEM; NLMIXED; Laplace; Gaussian quadrature; Back-Step Method; Proportional odds model; Differential odds model;

   Sammanfattning : Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. LÄS MER

3. 17. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

   Författare :Matts Kågedal; Mats Karlsson; Andrew C Hooker; Gitte Knudsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. LÄS MER

4. 18. Pharmacometrics to improve evaluation and individualization of anticancer drug treatment

   Författare :Sreenath Madathil Krishnan; Lena Friberg; Mats Karlsson; Zinnia Parra Gillén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacodynamics; survival modeling;

   Sammanfattning : The success rate in clinical development of newer anti-cancer molecules is the lowest compared to other major diseases. Improving the success rate and better early evaluation of efficacy of anti-cancer drugs remain challenging obstacles. LÄS MER

5. 19. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

   Författare :Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

   Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER

7. 20. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology

   Författare :Ida Netterberg; Lena Friberg; Mats Karlsson; Elisabet I. Nielsen; Henrik Lindman; Amit Roy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Biomarkers; Oncology; Population PKPD Modeling; NONMEM; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. LÄS MER