Sökning: "melanocyte"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet melanocyte.

1. 1. Epidermal Melanocyte Response to Radiotherapy

   Författare :Per Fessé; Henrik Lindman; Ingela Turesson; Johan Ahlgren; Jan Nyman; Catharine West; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanocytes; fractionated radiotherapy; ΔNp63; MITF; PAX3; SOX10; p53; p21; BMI1; pRb; CXCR2; DNA-DSB; 53BP1; CXCR2;

   Sammanfattning : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. LÄS MER

3. 2. UVA/B induced redox alterations and apoptosis in human melanocytes

   Författare :Petra Wäster Larsson; Inger Rosdahl; Karin Öllinger; Ian Cotgreave; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; UV; melanocyte; apoptosis; glutathione; p53; Dermatology and venerology; Dermatologi och venerologi;

   Sammanfattning : Malignant melanoma is one of the most rapidly increasing cancers and accounts for about three-quarter of all skin cancer deaths worldwide. Despite compelling evidence that ultraviolet (UV) irradiation causes melanoma the knowledge how various wavelength spectra affect the balance between proliferation and apoptosis controlling the homeostasis of the melanocyte population is still limited. LÄS MER

4. 3. Regulation of UV induced apoptosis in human melanocytes

   Författare :Cecilia Bivik; Inger Rosdahl; Karin Öllinger; Maria Shoshan; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; UV; melanocyte; lysosome; cathepsin; Bcl-2; Bax; Hsp70; JNK; Dermatology and venerology; Dermatologi och venerologi;

   Sammanfattning : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. LÄS MER

5. 4. alpha-Melanocyte-stimulating hormone in neurodegenerative processes

   Författare :Åsa Forslin Aronsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :alpha-MSH; excitotoxicity; gliosis; ischemia; memory; stereology;

   Sammanfattning : The fact that inflammatory processes accompany the neuronal cell death in most neurodegenerative disorders, has in recent years inspired to studies on the role of inflammation in the brain and the possibility to prevent or stop the degenerative processes by treatment with anti-inflammatory drugs. Neurodegenerative disorders are often accompanied by a progressive loss of memory, and substances that can improve memory functions are of great interest. LÄS MER

7. 5. The Role of Melanocyte Lineage Genes in Melanoma

   Författare :Adriana Sanna; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Genetic; Epigenetic; Heterogeneity; MITF; SOX10; CSD;

   Sammanfattning : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. LÄS MER