Sökning: "N-glycosylation"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet N-glycosylation.

  1. 1. Development and application of alternative methods for profiling proteins N-glycosylation

    Detta är en avhandling från Stockholm : Department of Environmental Science and Analytical Chemistry, Stockholm University

    Författare :Alessandro Quaranta; Stockholms universitet.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. LÄS MER

  2. 2. Aspects of N-glycosylation in human IgE

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Johanna Da Luz; Karolinska Institutet.; Karolinska Institutet.; [2002]

    Sammanfattning : The medical interest of allergy in industrialised societies has generated a much greater knowledge about the pathophysiology of IgE-mediated responses than about its normal physiological role. Because of the central role of IgE in allergic inflammation, neutralisation of effector functions and inhibition of IgE-synthesis are attractive means of therapy. LÄS MER

  3. 3. Heterologous expression and characterization of xyloglucan endotransglycosylases from Populus tremula x tremuloides

    Detta är en avhandling från Stockholm : Bioteknologi

    Författare :Åsa Kallas; KTH.; [2004]
    Nyckelord :xyloglucan endotransglycosylase; transglycosylation; hybrid aspen; cell expansion; heterologous expression; Pichia pastoris; N-glycosylation; X-ray crystallography;

    Sammanfattning : Xyloglucan endotransglycosylases (XETs) are enzymes involvedin the reorganization of the primary cell wall. This thesisdescribes several aspects of XET16A from hybrid aspen (Populustremula x tremuloides). The gene was isolated from the hybridaspen cDNA library and the protein was expressed heterologouslyin the methylotrophic yeast Pichia pastoris. LÄS MER

  4. 4. Targeting and function of CAH1 Characterization of a novel protein pathway to the plant cell chloroplast

    Detta är en avhandling från Umeå : Institutionen för fysiologisk botanik, Umeå universitet

    Författare :Stefan Burén; Umeå universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis; chloroplast; endomembrane system; CAH1; protein targeting; N-glycosylation; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The chloroplast is the organelle within a plant cell where photosynthesis takes place. This organelle originates from a cyanobacterium that was engulfed by a eukaryotic cell. LÄS MER

  5. 5. Glypican-1: Structural and functional analysis of the N-glycosylated human protein

    Detta är en avhandling från Department of Biochemistry and Structural Biology, Lund University

    Författare :Wael Awad Abdelhady; Lund University.; Lunds universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteoglycans; glypicans; glypican-1; heparan sulphate; N-glycosylation; exostosin-proteins; X-ray crystallography; crystal dehydration; diffraction anisotropy; Small angle X-ray scattering SAXS9; protein spectroscopy;

    Sammanfattning : Glypicans are multifunctional cell surface heparan sulphate proteoglycans co-regulating numerous signalling pathways, and are thereby involved in the control of cellular division, differentiation, and morphogenesis. The heparan sulphate (HS) chains are responsible for many of those biological functions; nevertheless recent studies suggest functional roles for the glypican core proteins in mediating the signalling of various growth factors. LÄS MER