Sökning: "Cell specific perfusion rate"
Hittade 5 avhandlingar innehållade orden Cell specific perfusion rate.
1. Tools for the development of intensified perfusion processes for mammalian cell culture
Sammanfattning : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. LÄS MER
2. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells
Sammanfattning : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. LÄS MER
3. Imaging the tumor microenvironment : the dynamics and modification of hypoxia
Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER
4. Making endothelial cells move : a study of angiomotin and binding partners
Sammanfattning : Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), a membrane-associated scaffold protein, plays an essential role in controlling endothelial cell migration and cellshape. LÄS MER
5. Pregnancy rhinitis : pathophysiological effects of oestrogen and treatment with oral decongestants
Sammanfattning : Pregnancy rhinitis, a common condition, is thought to affect about 20 % of pregnant women. This type of rhinitis may develop at any time during pregnancy and the nasal stuffiness usually disappears shortly after delivery. This condition is troublesome and can interfere with sleep, induce tiredness and dryness of the mouth. LÄS MER