Sökning: "Paper Spray Ionization"

Hittade 4 avhandlingar innehållade orden Paper Spray Ionization.

  1. 1. New methods for sensitive analysis with nanoelectrospray ionization mass spectrometry

    Författare :Patrik Ek; Johan Roeraade; Åsa Emmer; Andries P. Bruins; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; electrospray ionization; nanoelectrospray ionization; adjustable gap; emitter; miniaturization; improved sensitivity; nanoliter picoliter sample volumes; Alzheimer’s disease; amyloid-beta Aβ ; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis, new methods that address some current limitations in nanoelectrospray mass spectrometry (nESI-MS) analysis are presented. One of the major objectives is the potential gain in sensitivity that can be obtained when employing the proposed techniques. LÄS MER

  3. 2. New Materials and Improved Ambient Techniques in Mass Spectrometry

    Författare :Nicolò Riboni; Leopold Ilag; Elisa Robotti; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Solid Phase Microextraction; Ambient Mass Spectrometry; Desorption Electrospray Ionization; Paper Spray Ionization; Cavitands; BTEX; New Psychoactive Substances; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Mass spectrometry (MS) is used in several fields, e.g. biology, environmental monitoring, medicine and forensics due to excellent qualitative and quantitative capabilities. The development of new instrumental setups and ionization sources is crucial to analyze a variety of compounds at trace levels. LÄS MER

  4. 3. Development and application of alternative methods for profiling proteins N-glycosylation

    Författare :Alessandro Quaranta; Leopold Ilag; Niclas Karlsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. LÄS MER

  5. 4. Mass Spectrometry with Electrospray Ionization from an Adjustable Gap

    Författare :Patrik Ek; Åsa Emmer; Johan Roeraade; Per M. Claesson; Ulrika Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Electrospray ionization; mass spectrometry; nanoelectrospray; ESI; MS; chip; emitter; gap; liquid bridge; nozzle; peptides; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis the fabrication and analytical evaluation of two new electrospray emitters utilized for mass spectrometry analysis is presented. The emitters are based on a new concept, where the spray orifice can be varied in size. The thesis is based on two papers. All present-day nanoelectrospray emitters have fixed dimensions. LÄS MER