Sökning: "Major histocompatibility complex molecules"

Visar resultat 11 - 15 av 47 avhandlingar innehållade orden Major histocompatibility complex molecules.

  1. 11. MHC and Transgenic Mice. A study into polymorphism and function of class I and class II molecules

    Författare :Mikael Vestberg; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MHC rat mouse transgenic autoimmunity collagen peptide; Clinical biology; Klinisk biologi;

    Sammanfattning : Transplantation antigens encoded in the major histocompatibility complex (MHC) bind peptides and present them to T cells. We showed that mouse T cells expressing transgenic human CD8 can recognise human MHC class I. LÄS MER

  3. 12. Structural insights into glycoprotein transport and viral escape

    Författare :Lucas Malard Velloso; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; glycoprotein transport; endoplasmic reticulum; p58 ERGIC-53; MHC class I molecules; viral escape;

    Sammanfattning : The correct trafficking of proteins through the secretory pathway is essential for the maintenance of cellular functions. Increasing evidence suggests that at least for some glycoproteins, export from the endoplasmic reticulum (ER) is mediated by interaction with cargo receptors. LÄS MER

  4. 13. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

    Författare :Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

    Sammanfattning : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. LÄS MER

  5. 14. The quality control of MHC class I antigen presentation

    Författare :Kajsa M Paulsson; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperone; assembly; COPI; antigenic peptide; TAP; MHC; tapasin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). LÄS MER

  7. 15. MHC and genomic diversity in Atlantic salmon (Salmo salar L.)

    Författare :Jakob Lohm; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Djurekologi; cytogenetik; Genetik; cytogenetics; Genetics; nucleotide diversity; isolation-by-distance; DGGE; AFLP; furunculosis; disease resistance; Arctic charr; brown trout; Atlantic salmon; population genetics; genetic variation; Mhc class IIB; Animal ecology;

    Sammanfattning : In this thesis I present studies concerning genomic diversity and genetic heterogeneity as well as the evolution and maintenance of genetic variation at a specific immune defence gene in Atlantic salmon (Salmo salar, L.). LÄS MER