Sökning: "Major histocompatibility complex molecules"

Visar resultat 16 - 20 av 47 avhandlingar innehållade orden Major histocompatibility complex molecules.

1. 16. T cells in colon cancer; migration and effector functions

   Författare :Louis Szeponik; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Treg; CRC; TIL; nSMase2; Transendothelial migration; Unconventional T cells;

   Sammanfattning : Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated with a better patient outcome. LÄS MER

3. 17. MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells

   Författare :Adil Doganay Duru; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats by scanning a repertoire of peptide epitopes presented by major histocompatibility complex (MHC) molecules. LÄS MER

4. 18. Generation of Therapeutic T Cells for Prostate Cancer

   Författare :Ole Forsberg; Magnus Essand; Thomas Tötterman; Gustav Gaudernack; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; T cells; dendritic cells; peptides; cytomegalovirus; adenovirus; immunotherapy; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : The work presented herein focuses on the activation of the adaptive immune system in order to develop T cell-based immunotherapy for viral infections and cancer. The main goal was to identify and activate viral or tumoral antigen-specific T cells by using different identification, isolation and stimulation techniques. LÄS MER

5. 19. Experimental autoimmune sialadenitis : studies of immunopathogenesis, cellular signaling and MHC genetics

   Författare :Elwaleed Ibrahim Mustafa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Experimental autoimmune sialadenitis (EAS), an animal model for Sjogren´s syndrome (SS) in humans, develops spontaneously in certain mouse strains. A major feature of EAS and SS is infiltration of exocrine glands by mononuclear cells (MNC), and functional impairment of predominantly salivary and lachrymal glands leading to mouth and eye dryness. LÄS MER

7. 20. Immunity to Salmonella infection

   Författare :Cecilia Johansson; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; cytokines; antigen presentation; liver; dendritic cells; Salmonella; gram negative bacteria;

   Sammanfattning : The immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. LÄS MER