Sökning: "Jonas Bergquist"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden Jonas Bergquist.

  1. 1. Porphyrins and heme in microorganisms : Porphyrin content and its relation to phototherapy and antimicrobial treatments in vivo and in vitro

    Författare :Jonas Fyrestam; Conny Östman; Jonas Bergquist; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Porphyrins; heme; phototherapy; antimicrobial resistance; singlet oxygen; photosensitizer; bacteria; HPLC-MS MS; oral bacteria; Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis; Escherichia coli; Analytical Chemistry; analytisk kemi;

    Sammanfattning : One of the greatest threats to human health is increasing antimicrobial resistance among pathogens, and finding alternatives for treatment of bacterial infections is of highest importance together with a more controlled use of antibiotics. Porphyrins and heme have both been shown to be a promising class of compounds for inactivation of bacteria; porphyrins by their excellent properties to act as a photosensitizer, and heme by its importance as an iron source during a bacterial infection in vertebrates. LÄS MER

  2. 2. Development of Techniques and Methods for the Quantitative Analysis of Endogenous Substances by Microcolumn Liquid Chromatography Coupled to Mass Spectrometry

    Författare :Ardeshir Amirkhani; Jonas Bergquist; Karin E. Markides; Fritz Erni; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Liquid chromatography-mass spectrometry (LC-MS) is a powerful technique for the analysis of endogenous compounds. The introduction of electrospray ionization (ESI) as an interface between LC and MS has contributed strongly to a trend towards miniaturization of LC, due to the possibility to perform ESI at low flow rates. LÄS MER

  3. 3. Characterisation of Chromatography Media Aimed for Purification of Biomolecules

    Författare :Mikael Andersson; Bergquist Jonas; Bo-Lennart Johansson; Jan-Christer Janson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Chromatography; Media; Characterisation; Stability; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Chromatography media (resins) are very important for and widely used by the biopharma industry in large scale production of biopharmaceuticals, e.g. monoclonal antibodies. Today there are several hundred biopharmaceuticals released globally on the healthcare market. LÄS MER

  4. 4. Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds

    Författare :Björn Arvidsson; Jonas Bergquist; Magnus Wetterhall; Gérard Hopfgartner; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Analytical chemistry; Method development; Enhanced microdialysis; Column switching; Liquid chromatography; Capillary electrophoresis; Electrospray ionization; Mass spectrometry; Triple quadrupole; Time-of-flight; Quantitation; Validation; Analytisk kemi;

    Sammanfattning : Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the ruggedness of the method acquiring the results. In addition to the complexity of the sample matrix, the bioactive compounds targeted for analysis usually have low levels of natural abundance, further increasing the demand on the analytical method sensitivity. LÄS MER

  5. 5. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

    Författare :Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : .... LÄS MER