Sökning: "Johan Ankarklev"

Hittade 4 avhandlingar innehållade orden Johan Ankarklev.

  1. 1. Inter and Intra-Assemblage Characterizations of Giardia intestinalis: from clinic to genome

    Författare :Johan Ankarklev; Staffan Svärd; Johanna P. Daily; Uppsala universitet; []
    Nyckelord :Giardia; protozoa; parasite infection; diarrhea; genome sequencing; comparative genomics; genotyping; ASH; MLG; Infektionssjukdomar; Infectious Diseases; Molekylär medicin; Molecular Medicine; Mikrobiologi; Microbiology;

    Sammanfattning : The protozoan parasite Giardia intestinalis (syn. G. lamblia, G. duodenalis) is one of the most common causes of diarrheal disease throughout the world, where an estimated 500 million people are infected annually. LÄS MER

  3. 2. Peripheral apolipoprotein E and its emerging role in neurodegenerative disease

    Författare :Andreas Giannisis; Henrietta M. Nielsen; Kim Kultima; Johan Ankarklev; Cheryl Wellington; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; humanized-liver mice; race; diet; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The human apolipoprotein E gene (APOE) is polymorphic and coding for three common alleles; ε2, ε3, and ε4. Carriers of the ε4 allele are at a higher risk of developing sporadic late-onset Alzheimer’s Disease (AD). This association appears to be influenced by inherited traits, race, and sex. LÄS MER

  4. 3. Host-parasite interactions in space and time

    Författare :Franziska Hildebrandt; Johan Ankarklev; Volker T. Heussler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; liver-stage infection; Toxoplasma; host-parasite interactions; spatial transcriptomics; single-cell omics; single-cell Dual-seq; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Unicellular parasites of the apicomplexan phylum have a considerable effect on global health and agriculture. Two prominent examples of this phylum include malaria causing parasites of the Plasmodium genus and the widely prevalent parasite Toxoplasma gondii. LÄS MER

  5. 4. Uncovering the genetics underlying host-parasite interactions during Plasmodium falciparum malaria transmission

    Författare :Mubasher Mohammed; Johan Ankarklev; David Serre; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; Plasmodium falciparum; Genomics; single-cell RNA-seq; Parasite cell fate; Anopheles gambiae; ApiAP2 transcription factors; driver genes; computational biology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : In eukaryotes, cellular differentiation is often orchestrated by programmed arrays of activation and repression of genes underlying the specific phenotypes of cell-types. To complete its life cycle, the single-celled Apicomplexan parasite Plasmodium falciparum, the most deadly of the human malaria parasites, must repeatedly differentiate and convert into unique cell types that can exploit niches within their human and mosquito hosts. LÄS MER