Sökning: "prostaglandin E synthase"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden prostaglandin E synthase.

  1. 1. Studies of prostaglandin E2 formationin human monocytes

    Författare :Sofia Karlsson; Jonny Wijkander; Christina Gustafson-Svärd; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin E2; arachidonic acid; phospholipase A2; cyclooxygenase; prostaglandin E synthase; human monocytes; Medical cell biology; Medicinsk cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. LÄS MER

  3. 2. Structure and function of microsomal prostaglandin E synthase-1

    Författare :Sven-Christian Pawelzik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of inflammation, pain, and fever. LÄS MER

  4. 3. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Författare :Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. LÄS MER

  5. 4. Prostaglandin E2 in Brain-mediated Illness Responses

    Författare :Louise Elander; Anders Blomqvist; Marianne Schultzberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin e2; PGE2; cox-1; cox-2; mPGES-1; fever; anorexia; food intake; HPA-axis; EP-receptor; LPS; IL-1; IL-6; MEDICINE; MEDICIN; Neurobiology; Neurobiologi;

    Sammanfattning : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. LÄS MER

  7. 5. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism

    Författare :Linda Spahiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. LÄS MER